Transition-state stabilization and molecular recognition: Acceleration of phosphoryl-transfer reactions by an artificial receptor

Article abstract of DOI:10.1021/ja00182a017

An artificial receptor that is complementary to the proposed trigonal-bipyramidal intermediate for phosphoryl-transfer reactions has been designed. Kinetic measurements with ³¹P NMR methods show that the receptor causes up to a 10-fold acceleration in the aminolysis of phosphorodiamidic chloride derivatives, proceeding via an associative mechanism.