RNA hydrolysis by the combination of the lanthanum(III) ion and hydrogen peroxide

Article abstract of DOI:10.1246/cl.1996.869

Diribonucleotides are efficiently hydrolyzed by the combination of the lanthanum(III) ion and hydrogen peroxide at pH 7.2 and 30 °C. The rate constant for the hydrolysis of adenylyl(3′-5′)adenosine by the mixture of La(ClO₄)₃ (10 mmol dm^-3) and H₂O₂ (100 mmol dm^-3) is 7.7 x 10^-2 min^-1 (half-life 9 min), corresponding to a 460 fold cooperative promotion of the catalysis.