Tetrahedron Letters p. 5307 - 5310 (1987)
Update date:2022-08-11
Topics:
Rueffer, M.
Zenk, M. H.
A microsomal cytochrome P-450-NADPH dependent enzyme which hydroxylates stereo- and regiospecifically carbon atom 14 of (S)-cis-N-methyltetrahydroprotoberberines has been discovered in a number of plant cell cultures originating from species containing protopine alkaloids; the monooxygenase was solubilized, partially purified (100-fold) and characterized.
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