Synthesis of α-fluoro-β,γ-alkenylphosphonates and conjugated fluoroenynes from a common intermediate (α-fluoropropargyl) phosphonate

Article abstract of DOI:10.1016/S0040-4020(98)01017-5

The efficient preparation of a-fluoro-β,γ,-alkenylphosphonate 3, via catalytic hydrogenation of (α-fluoropropargyl)phosphonate ester 1, is described. Conjugated fluoroenynes 4 have been synthesized using a modified Homer Wadsworth Emmons (HWE) olefination