4-Substituted uridine 5′-triphosphates as agonists of the P2y2 purinergic receptor

Article abstract of DOI:10.1080/07328319708006141

Undine 5′-O-triphosphate (UTP) is a potent agonist of the purinergic receptor designated P_2Y2. UTP is rapidly metabolized in human tissue. To find a compound with similar activity that may be more slowly metabolized, a series of 4-substituted uridine 5′-triphosphates were prepared and evaluated in a P_2Y2 receptor second messenger assay. Copyright

Full text of DOI:10.1080/07328319708006141

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Nucleosides and Nucleotides
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4-Substituted Uridine 5′-Triphosphates
as Agonists of the P2Y2 Purinergic
Receptor
Sammy R. Shaver a , William Pendergast a , Suhaib M. Siddiqi a
,
Benjamin R. Yerxa a , Dallas K. Croom a , Robert W. Dougherty a
Michael K. James a , A. Neil Jones a & Janet L. Rideout a
,
a Inspire Pharmaceuticals, Inc., 4222 Emperor Boulevard Suite
470, Durham, NC, 27703
Published online: 16 Aug 2006.
To cite this article: Sammy R. Shaver , William Pendergast , Suhaib M. Siddiqi , Benjamin R.
Yerxa , Dallas K. Croom , Robert W. Dougherty , Michael K. James , A. Neil Jones & Janet L.
Rideout (1997) 4-Substituted Uridine 5′-Triphosphates as Agonists of the P2Y2 Purinergic Receptor,
Nucleosides and Nucleotides, 16:7-9, 1099-1102, DOI: 10.1080/07328319708006141
To link to this article: http://dx.doi.org/10.1080/07328319708006141
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