Tetrahedron Letters p. 6861 - 6864 (1997)
Update date:2022-08-23
Topics:
Kosugi, Hiroshi
Hoshino, Kunihide
Uda, Hisashi
Highly enantioselective protonation of prochiral lithium enolates is disclosed. The present method employed (S,R(s)) CF3-hydroxy sulfoxide (3b) as the chiral protonating agent, and the protonation or lithium enolates of cyclohexanone derivatives with 3b proceeded with high enantioselectivities.
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