Journal of the Chemical Society. Perkin transactions I p. 2779 - 2785 (1981)
Update date:2022-08-10
Topics:
Battersby, Alan R.
Buckley, Dennis G.
Johnson, Dawid W.
Mander, Lewis N.
McDonald, Edward
Williams, D. Clive
The unrearranged pyrromethane (1) is transformed chemically mainly into uro'gen-I with a smaller amount of uro'gen-IV but only traces of uro'gen-III are formed.Uro'gen-I is produced via a tetrapyrrolic (bilane) intermediate and when the diaminase-cosynthetase enzyme system from Euglena gracilis is present, this intermediate is converted into uro'gen-III.The rearrangement step for this conversion has the same characteristics found earlier for the natural biosynthetic process from porphobilinogen.Pyrromethane (1) is not a direct biosynthetic precursor of uro'gen-III and reasons are advanced why this is understandable.Methods are developed based on high pressure liquid chromatography for the separation of all four isomeric coproporphyrin esters.
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Doi:10.1021/ja00371a064
(1982)Doi:10.1016/S0040-4039(01)00552-4
(2001)Doi:10.3390/molecules26092692
(2021)Doi:10.1016/S0277-5387(99)00358-7
(2000)Doi:10.1016/S0040-4039(02)00733-5
(2002)Doi:10.1007/BF01517095
(1880)
