
Canadian Journal of Chemistry p. 641 - 645 (1997)
Update date:2022-07-29
Topics:
De La Cruz, Ricardo A.
Talamas, Francisco X.
Vazquez, Alfredo
Muchowski, Joseph M.
A total synthesis of mycophenolic acid is reported. Diels-Alder reaction of [5-methoxy-3-(1-methoxypropenyl)-4,5-dihydrofuran-2-yloxy]-trimethylsilane with 3-benzenesulfinyl-5H-furan-2-one afforded the hexasubstituted nucleus. The side chain was constructed from the unveiled aldehyde. A total synthesis of mycophenolic acid is reported. Diels-Alder reaction of [5-methoxy-3-(1-methoxypropenyl)-4, 5-dihydrofuran-2-yloxy]-trimethylsilane with 3-benzenesulfinyl-5H-furan-2-one afforded the hexasubstituted nucleus. The side chain was constructed from the unveiled aldehyde.
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