Microbial hydroxylation and functionalization of synthetic polycyclic enones

Article abstract of DOI:10.1016/S0957-4166(00)80241-4

The regio- and stereoselective hydroxylation of variously substituted asymmetric 4a-methyl octalenones by selected fungal strains has been shown to afford, sometimes in high yields, several optically pure derivatives, generally hydroxylated in the B-ring. The potential of this method for the preparation of functionalized (hydroxylated) chiral synthons is evaluated and discussed.