Bioorganic and Medicinal Chemistry Letters p. 2473 - 2478 (1998)
Update date:2022-08-11
Topics:
Tsuji, Kiyoshi
Ogino, Takashi
Seki, Nobuo
Sawada, Masae
Sudo, Yu
Nishigaki, Fusako
Manda, Toshitaka
Matsuo, Masaaki
5-(2-Pyridylsulfonyl)-2-thiazolamine (2) was effective both in mitomycin C (MMC)-induced thrombocytopenia and in an animal model of idiopathic thrombocytopenic purpura (ITP). It also suppressed the increase of autoantibodies against platelets in the ITP model and showed no blood toxicity. Chemical modification of 2 led to the discovery of more potent compounds against MMC-induced thrombocytopenia.
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