Synthesis and effects of novel thiazole derivatives against thrombocytopenia

DOI: 10.1016/S0960-894X(98)00404-1

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2473 - 2478 (1998)

Update date:2022-08-11

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Authors:

Tsuji, Kiyoshi

Ogino, Takashi

Seki, Nobuo

Sawada, Masae

Sudo, Yu

Nishigaki, Fusako

Manda, Toshitaka

Matsuo, Masaaki

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Article abstract of DOI:10.1016/S0960-894X(98)00404-1

5-(2-Pyridylsulfonyl)-2-thiazolamine (2) was effective both in mitomycin C (MMC)-induced thrombocytopenia and in an animal model of idiopathic thrombocytopenic purpura (ITP). It also suppressed the increase of autoantibodies against platelets in the ITP model and showed no blood toxicity. Chemical modification of 2 led to the discovery of more potent compounds against MMC-induced thrombocytopenia.

Full text of DOI:10.1016/S0960-894X(98)00404-1

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