Iterative Arylation of Itaconimides with Diazonium Salts through Electrophilic Palladium Catalysis: Divergent β-H-Elimination Pathways in Repetitive Matsuda-Heck Reactions

DOI: 10.1021/acs.joc.9b00627

Source and publish data:

Journal of Organic Chemistry p. 5732 - 5746 (2019)

Update date:2022-08-15

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Authors:

Riemer, Nastja

Shipman, Michael

Wessig, Pablo

Schmidt, Bernd

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Article abstract of DOI:10.1021/acs.joc.9b00627

N-Arylitaconimides, accessible from maleic anhydride, anilines, and paraformaldehyde, react with arene diazonium salts in Pd-catalyzed Matsuda-Heck arylation to the pharmacologically relevant E-configured 3-arylmethylidene pyrrolidine-2,5-diones (also kno

Full text of DOI:10.1021/acs.joc.9b00627

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