Chemical and Pharmaceutical Bulletin p. 412 - 414 (1997)
Update date:2022-08-11
Topics:
Kitaori, Kazuhiro
Takehira, Yoshikazu
Furukawa, Yoshiro
Yoshimoto, Hiroshi
Otera, Junzo
The synthesis of (R)- and (S)-atenolol (1) was achieved in two steps starting from p-hydroxyphenylacetamide (2). Both enantiomers of the glycidyl ether 4 were synthesized from 2 and (R)- and (S)-epichlorohydrin (3) using an alkali metal hydroxide and/or BTA (benzyltrimethylammonium chloride), respectively. Subsequent treatment of 4 with isopropylamine afforded atenolol (1) with excellent enantiomeric excess (> 98% ee).
View More
Contact:+(852) 301-98033
Address:Flat C, 23/F, Lucky Plaza, 315-321 Lockhart Road, Wan Chai, Hong Kong
Shanghai Massive Chemical Technology Co., Ltd.
website:http://www.massivechem.com/
Contact:+86 21 34943721
Address:Room 435, 4th floor, Building 9, No. 2568 Gudai Road,Minhang District, Shanghai,
Contact:+86-21-54391580
Address:Room 502,No.65,Lane 2388 Hongxin Road,Shanghai,China
Suzhou Time-chem Technologies Co., Ltd.
Contact:0512-63983931/68086856
Address:No. 1326 of Binhe Road, New District, Suzhou, Jiangsu, P. R. China
Shanghai Micro-mega Industry Co., Ltd.
Contact:0086-21-34628682;57153848
Address:Rm413,No.413,West Meilong Road, Minhang District,Shanghai P R China
Doi:10.1021/ic50060a045
(1968)Doi:10.1039/d0ob02359k
(2021)Doi:10.1016/S0022-328X(00)84568-4
(1971)Doi:10.1074/jbc.RA118.001980
(2018)Doi:10.1039/c9cy01791g
(2019)Doi:10.1039/c5ra05418d
(2015)
