GLYCOSYLATION WITH HIGHLY REACTIVE GLYCOSYL DONORS: EFFICIENCY OF THE INVERSE PROCEDURE

Article abstract of DOI:10.1016/S0040-4039(00)92704-7

α-Fucosylation with the reactive trichloroacetimidate 1 as donor and disaccharides 2 and 4 as acceptors led to a remarkable increase in yield under "inverse conditions", i. e. addition of the donor to an acceptor/catalyst solution.Thus, acceptor/catalyst complex formation enforcing the generation of the glycosylation species in the vicinity of the acceptor is favored yielding building blocks for antigen determinant synthesis.