Stereoselective synthesis of hydroxy-ketenedithioacetals from aldehydes

Article abstract of DOI:10.1016/S0040-4020(98)00413-X

The reaction of Garner's aldehyde with dithioacetate enethiolates followed by alkylation of the intermediate aldolate gives hydroxy- ketenedithioacetals with a moderate anti selectivity. This methodology was applied to the synthesis of various other ketene dithioacetals with high E or Z stereoselectivity.