Electrophilic substitution of asymmetrically distorted benzenes within triptycene derivatives

Article abstract of DOI:10.1021/acs.orglett.1c00970

Herein, we disclose a unique directing effect of 9-substituted triptycenes in electrophilic substitution to achieve the regioselective functionalization of the triptycene core. The Hirshfeld population analysis was adopted to predict the selectivity in el