Anti-selective asymmetric aldol reactions. Enantioselective synthesis of anti-αβ-dihydroxy phenyl ester derivatives

Article abstract of DOI:10.1016/S0040-4039(00)76899-7

In the presence of a chiral tin(II) Lewis acid, the silyl enol ether derived from (E)-phenyl α-t-butyldimethylsiloxyacetate reacted with aldehydes to afford the corresponding anti-aldol adducts, anti-α,β-dihydroxy ester derivatives, in high yields with hi