New neplanocin analogues. IX. A practical preparation of (6'R)-6'-C- methylneplanocin A (RMNPA), a potent antiviral agent, and the determination of its 6'-configuration. Diastereoselective deamination by adenosine deaminase

DOI: 10.1248/cpb.45.138

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Chemical and Pharmaceutical Bulletin p. 138 - 142 (1997)

Update date:2022-08-11

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Authors:

Shuto, Satoshi

Obara, Takumi

Yaginuma, Satoshi

Matsuda, Akira

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Article abstract of DOI:10.1248/cpb.45.138

We previously synthesized (6'R)- and (6'S)-6'-C-methylneplanocin A's (2a and 2b, respectively), and found that one of them has a potent antiviral activity, though its 6'-configuration has not been confirmed. This report describes the determination of the

Full text of DOI:10.1248/cpb.45.138

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