Confocal microscopy imaging implied that FB can be potentially
used as a promising candidate for Fe and PPi imaging in Hep
G2 cell.
37. Takashima, I.; Kinoshita, M.; Kawagoe, R.; Nakagawa, S.;
3+
Sugimoto,M.; Hamachi, I., Ojida, A. Chem. Eur. J. 2014, 20,
2
184-2192.
3
3
4
8.
Meng, Q.T.; Wang, Y.; Yang, M.; Zhang, R.; Wang, R. J.;
Zhang,Z.Q. RSC Adv. 2015, 5, 53189-53197.
Acknowledgements
9. Bender, D. R.; Kanne, D.; Frazier, J. D.; Rapoport, H. J.
Org.Chem.1983, 8, 2709-2719.
0. Synthesis and Characterization the fluorescence probe FB
This work was supported by National Natural Science
Foundation of China (21506106) and the Key Laboratory Project
of Liaoning Province (2008S127)
L-Histidine (0.512g,
3
mmol), 7-hydroxy-4-methyl-2-oxo-2H-
chromene-8-carbaldehyde (2) (0.673 g, 3.3 mmol) and 20 mL acetic
acid as solvent were added to a round flask and the mixture was stirred
and refluxed for 12 h to yield a yellow precipitate. After cooling to
room temperature, the precipitate was filtered, washed with methanol
and dried under vacuum to obtain FB in 68% yield without other
purification. m. p. 202.5-203.7ºC; FT-IR (KBr): 3435, 3094, 1709,
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