ENANTIOSELECTIVE CATALYTIC BORANE REDUCTIONS OF ACHIRAL KETONES: SYNTHESES AND APPLICATION OF TWO CHIRAL β-AMINO ALCOHOLS FROM (S)-2-INDOLINE CARBOXYLIC ACID

Article abstract of DOI:10.1016/S0957-4166(00)80271-2

The synthesis of (S)-α,α-diphenyl-(indolin-2-yl)methanol 1 makes available the chiral oxazaborolidine 2 which is an excellent catalyst for borane reduction of prochiral ketones to chiral secondary alcohols, e.g. acetophenone, in high optical purity.The ne