Chemistry Letters p. 433 - 436 (1989)
Update date:2022-08-15
Topics:
Kusumi, Akihiro
Nakahama, Seiichi
Yamaguchi, Kazuo
Photo-labile phosphatidylcholine (PLPC) was synthesized which contains 2-nitrobenzyl esters at the terminals of both alkyl chains.Photolysis of the esters generates carboxylate ions in the hydrophobic region of the PLPC membrane, leading to instant disintegration of PLPC liposomes as observed by the phase contrast microscopy.Upon UV irradiation, entrapped macromolecules (45-kdalton ovalbumin) were released from PLPC liposomes.
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