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Chemical Science
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ARTICLE(
Journal(Name(
promoting( electronic( transfer( at( the( ligand( instead,( thus(
limiting(uncontrolled(reactivities(at(the(metal(center,(and(was(
successfully( applied( to( the( trifluoromethylation( of( silyl( enol(
ethers,( heteroaromatics( and( hydrotrifluoromethylation( of(
alkynes.(To(the(best(of(our(knowledge,(this(is(the(first(example(
of( hydrotrifluoromethylation( of( alkynes( catalyzed( by( a( wellB
defined(copper(complex(and(overall(of(controlled(generation(
20( S.( Purser,( P.( R.( Moore,( S.( Swallow( and( V.( Gouverneur,( Chem.!
DOI: 10.1039/C5SC03636D
Soc.!Rev.,(2008,(37,(320.(
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22( T.( Yamazaki,( T.( Taguchi( and( I.( Ojima,( Unique! Properties! of!
!Fluorine! and! Their! Relevance! to! Medicinal! Chemistry! and!
Chemical!!Biology,(WileyBBlackwell,(Chichester,(2009.(
23( J.( Wang,( M.( SánchezBRoselló,( J.( L.( Aceña,( C.( del( Pozo,( A.( E.(
Sorochinsky,(S.(Fustero,(V.(A.(Soloshonok(and(H.(Liu,(Chem.!Rev.,(
2014,(114,(2432.(
24( C.(Alonso,(E.(Martínez(de(Marigorta,(G.(Rubiales(and(F.(Palacios,(
Chem.!Rev.,(2015,(115,(1847.(
25( T.(Furuya,(A.(S.(Kamlet(and(T.(Ritter,(Nature,(2011,(473,(470.(
26( C.(Hollingworth(and(V.(Gouverneur,(Chem.!Commun.,(2011,(48,(
2929.(
!
of(CF3 (radicals(by(cooperative(redox(catalysis.(This(reactivity(
opens(the(way(towards(new(developments(in(the(field(of(redox(
ligandBbased(cooperative(catalysis(as(possible(mild(alternatives(
to( expensive( noble( metals( such( as( iridium( and( ruthenium.(
Among( other( foreseeable( broad( catalytic( perspectives,( the(
participative( nature( of( these( ligands( could( allow( them( to(
stabilize( high( and/or( disfavored( metallic( oxidation( states,(
which(is(a(prospect(we(are(currently(pursuing.(
27( O.( A.( Tomashenko( and( V.( V.( Grushin,( Chem.! Rev.,( 2011,( 111,(
4475.(
28( X.BF.(Wu,(H.(Neumann(and(M.(Beller,(Chem.!–!Asian!J.,(2012,(7,(
1744.(
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Acknowledgements(
The(authors(thank(MENRT((JJ),(UPMC,(CNRS,(ANR(for(funding( 30( S.BM.( Wang,( J.BB.( Han,( C.BP.( Zhang,( H.BL.( Qin( and( J.BC.( Xiao,(
Tetrahedron,(2015,(71,(7949.(
(grant(ANRB11BJS07B004B01),(IUF((LF)(and(LabEx(MiChem.(The(
authors( also( wish( to( thank( LiseBMarie( Chamoreau( for( XBray(
analysis.(
31( T.(Liu,(T.(and(Q.(Shen,(Eur.!J.!Org.!Chem.,(2012,(6679.(
32( E.(J.(Cho,(T.(D.(Senecal,(T.(Kinzel,(Y.(Zhang,(D.(A.(Watson(and(S.(L.(
Buchwald,(Science,(2010,(328,(1679.(
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49,(9322.(
Notes(and(references(
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6(|(J.!Name.,(2012,(00,(1B3(
This(journal(is(©(The(Royal(Society(of(Chemistry(20xx(
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