Bioorganic and Medicinal Chemistry Letters p. 1241 - 1243 (2001)
Update date:2022-08-16
Topics:
Boehme, Thomas M.
Keim, Christine
Dannhardt, Gerd
Mutschler, Ernst
Lambrecht, Guenter
In our search for M2-selective muscarinic receptor antagonists, we synthesized 1,3-disubstituted indenes. The effects of different basic moieties with regard to binding and selectivity towards the five distinct muscarinic receptor subtypes were investigated. The results show that the quinuclidine series afforded the most promising compounds in terms of both receptor affinity and M2-subtype selectivity.
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