Synthesis of Both Enantiomers of Phoracantholide I, a Defensive Secretion of the Eucarypt Longicorn, Employing Asymmetric Reduction with Immobilized Baker's Yeast

Article abstract of DOI:10.1246/cl.1987.2379

Highly enantiomerically pure (R)- and (S)-phoracantholide I were synthesized in relatively short steps starting from diethyl 3-oxoglutarate by means of an asymmetric reduction of the intermediate keto acid with immobilized baker's yeast.The asymmetric reduction with the immobilized baker's yeast gave greater facilities compared with the analogous reaction with free baker's yeast.