Orally bioavailable benzisothiazolone inhibitors of human leukocyte elastase

DOI: 10.1021/jm00005a001

Source and publish data:

Journal of Medicinal Chemistry p. 739 - 744 (1995)

Update date:2022-08-10

Topics:

Authors:

Hlasta Hlasta

Subramanyam

Bell Bell

Carabateas

Court Court

Desai Desai

Drozd Drozd

Eickhoff

Ferguson

Gordon Gordon

Johnson Johnson

Kumar Kumar

Maycock Maycock

Mueller Mueller

Pagani Pagani

Robinson

Saindane

Silver Silver

Subramanian

et al. et al.

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Article abstract of DOI:10.1021/jm00005a001

Human leukocyte elastase (HLE) has been proposed as a primary mediator of pulmonary emphysema and other inflammatory airway diseases. HLE is capable of cleaving many proteins, including elastin, other components of connective tissue, certain complement pr

Full text of DOI:10.1021/jm00005a001

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