Conversion of a thiohydantoin to the corresponding hydantoin via a ring-opening/ring closure mechanism

DOI: 10.1016/0040-4039(96)01735-2

Source and publish data:

Tetrahedron Letters p. 7727 - 7730 (1996)

Update date:2022-08-03

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Authors:

Goubet, Francois

Teutsch, Georges

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Article abstract of DOI:10.1016/0040-4039(96)01735-2

The treatment of activated N,N' disubstituted arylthiohydantoins with methyl or ethyl iodide and sodium methoxide in DMF at room temperature affords the corresponding hydantoins in good yield. The mechanism involves an unusual ring opening-ring closure se

Full text of DOI:10.1016/0040-4039(96)01735-2

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