An Effective Preparation of Tetrahydropyran-(3R)-Carboxaldehyde, a Key Intermediate for the Synthesis of a Novel 5-Lipoxygenase Inhibitor

Article abstract of DOI:10.1016/S0957-4166(00)80513-3

A novel process based on the efficient resolution of rac-2 and suitable for preparing kilogram quantities of the chemically sensitive aldehyde tetrahydropyran-3R-carboxaldehyde R-2 of >=98percent ee is described.