ENANTIOSELECTIVE CATALYTIC BORANE REDUCTIONS OF ACHIRAL KETONES: SYNTHESIS AND APPLICATION OF NEW CHIRAL β-AMINO ALCOHOLS FROM L-METHIONINE

Article abstract of DOI:10.1016/S0957-4166(00)82245-4

The in situ formed chiral axazaborolidine catalysts from optically active β-amino alcohols 1-3 from L-methionine ethyl carboxylate 4 have been used successfully in the enantioselective catalytic homogenous borane reductions of various aromatic ketones.The corresponding optically active alcohols are obtained in high optical purity (up to 100percent ee).