NMR investigations of the conformation of new cyclodextrin-based amphiphilic transporters for hydrophobic drugs: molecular lollipops

Article abstract of DOI:10.1016/0022-2860(92)87087-C

Amphiphilic compounds, obtained by grafting aliphatic acids onto a modified cyclodextrin, have been synthesized and studied by solution NMR.The large chain-length dependence of the NMR spectra in aqueous media is explained by the possible formation of auto-inclusion complexes.This process has been evidenced by extensive NMR experiments and by competition with potential guests.This new class of molecules ("lollipops") provides important information for the optimization of a design for amphiphilic transporters to be included in organized phases such as micelles or liposomes.