Asymmetric synthesis of diethyl α-amino-α-alkyl-phosphonates by alkylation of chiral phosphonoglycine equivalents: Role of chelating effects

Article abstract of DOI:10.1016/S0957-4166(00)82094-7

Diethyl α-amino-α-alkyl-phosphonates are obtained in good to high enantiomeric excesses by alkylation of chiral phosphonoglycine equivalents embodying the camphor skeleton. The chelating effects in the alkylation step play an important role in enhancing t