Strategic use of retro Diels-Alder reaction in the construction of β-carboxy-α-methylene-γ-lactones. Total synthesis of methylenolactocin and protolichesterinic acid

Article abstract of DOI:10.1016/S0040-4020(97)10157-0

A facile route for the construction of β-carboxy-α-methylene-γ-lactone unit is described using retro Diels-Alder reaction as the key step. Using this protocol, total synthesis of (±)-methylenolactocin and (±)-protolichesterinic acid has been achieved.