The synthesis of 2-fluoropurine nucleosides

Article abstract of DOI:10.1080/15257779408013271

2-Aminoadenosine, obtained by silylation-amination from guanosine, is readily converted by KNO₂/HF/Pyridine in up to 80% yield into 2- fluoradenosine, which is a convenient starting material for the preparation of 9(β-D-arabinofuranosyl)-2-fluoroadenine 5'-phosphate (Fludara). N⁶,N⁶- Pentamethylene-2-aminoadenosine and guanosine afford likewise the corresponding 2-fluoropurine nucleosides in high yields.

Full text of DOI:10.1080/15257779408013271

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Nucleosides and Nucleotides
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The Synthesis of 2-Fluoropurine
Nucleosides
K. Krolikiewicz a & H. Vorbrüggen a
a Research Laboratories , Schering AG, 13342, Berlin, Germany
Published online: 23 Sep 2006.
To cite this article: K. Krolikiewicz & H. Vorbrüggen (1994) The Synthesis of 2-Fluoropurine
Nucleosides, Nucleosides and Nucleotides, 13:1-3, 673-678, DOI: 10.1080/15257779408013271
To link to this article: http://dx.doi.org/10.1080/15257779408013271
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Evaluation Only. Created with Aspose.PDF. Copyright 2002-2021 Aspose Pty Ltd.

Evaluation Only. Created with Aspose.PDF. Copyright 2002-2021 Aspose Pty Ltd.

Evaluation Only. Created with Aspose.PDF. Copyright 2002-2021 Aspose Pty Ltd.