Modifdied Oligonucleotides. Effect of 4 vs 5-atom Chimeric Internucleoside Linkages on Duplex Stability

DOI: 10.1016/0040-4039(95)01320-H

Source and publish data:

Tetrahedron Letters p. 6387 - 6390 (1995)

Update date:2022-08-11

Topics:

Authors:

Stork, Gilbert

Zhang, Chengzhi

Gryaznov, Sergei

Schultz, Ronald

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Article abstract of DOI:10.1016/0040-4039(95)01320-H

The question whether a four or a five atom non phosphorus based internucleoside link leads to stronger binding of the resulting chimeric oligonucleotides to complementary sequences has been examined by comparing melting temperatures of relevant duplexes.

Full text of DOI:10.1016/0040-4039(95)01320-H

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