Synthesis Using a Fmoc-Based Strategy and Biological Activities of Some Reduced Peptide Bond Pseudopeptide Analogues of Dynorphin A

Article abstract of DOI:10.1021/jm00018a006

Eight analogues of Dyn A(1-11)-NH2 incorporating the enzymatically stable Ψ(CH2-NH) isosteric peptide bond replacement were synthesized and tested for binding affinity at the central opioid μ, δ, and κ receptors in guinea pig brain (GPB) homogenates and f