Synthesis and Study of the Potential Antiallergic Activity of Some Pyrazole Derivatives

Article abstract of DOI:10.1021/jm00133a025

The synthesis and study of the oral antiallergic activity of a series of monopyrazole derivatives (2-14) considered as analogues of active bispyrazole 1 are described.None of the compounds showed significant inhibition of the rat passive cutaneous anaphylaxis (PCA), with the exception of the already known 5-aminoindazole (2).The activity of this compound is, however, lower than that of compound 1.