Bioorganic and Medicinal Chemistry Letters p. 2225 - 2230 (1996)
Update date:2022-08-16
Topics:
Klein, Scott I.
Dener, Jeffrey M.
Molino, Bruce F.
Gardner, Charles J.
D'Alisa, Rose
Dunwiddie, Christopher T.
Kasiewski, Charles
Leadley, Robert J.
A series of analogs were prepared based on the known thrombin inhibitor PPACK, in which the D-Phe-Pro dipeptide has been replaced by trans-4-O-benzyl hydroxyproline. One of these analogs is a more potent inhibitor of thrombin, and is more selective, than PPACK itself.
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