Asymmetric Synthesis of Chiral, Nonracemic Dialkyl-α-, β-, and γ-Hydroxyalkylphosphonates via a Catalyzed Enantioselective Catecholborane Reduction

Article abstract of DOI:10.1016/0957-4166(95)00132-9

A highly enantioselective synthesis of dialkyl α-hydroxyphosphonates achieved by a oxazaborolidine catalyzed reduction with catecholborane starting with α-ketophosphonates is described.Both α-aryl- and α-alkylketophosphonates were reduced using the (S)-en