Cyclic GMP phosphodiesterase inhibitors. 1. The discovery of a novel potent inhibitor, 4-((3,4-(methylenedioxy)benzyl)amino)-6,7,8- trimethoxyquinazoline

DOI: 10.1021/jm00076a003

Source and publish data:

Journal of Medicinal Chemistry p. 3765 - 3770 (1993)

Update date:2022-08-11

Topics:

Authors:

Takase Takase

Saeki Saeki

Fujimoto

Saito Saito

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Article abstract of DOI:10.1021/jm00076a003

A newly synthesized compound, 4-((3,4-(methylenedioxy)benzyl)amino)- 6,7,8-trimethoxyquinazoline (6), had a potent (IC₅₀ = 0.36 μM) inhibitory action on cyclic GMP phosphodiesterase (cGMP-PDE) isolated from porcine aorta; its inhibitory activit

Full text of DOI:10.1021/jm00076a003

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