Taxol structure-activity relationships: Synthesis and biological evaluation of 2-deoxytaxol

DOI: 10.1016/S0040-4039(00)73661-6

Source and publish data:

Tetrahedron Letters p. 3205 - 3206 (1993)

Update date:2022-08-25

Topics:

Authors:

Chen Chen

Wei Wei

Farina Farina

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Article abstract of DOI:10.1016/S0040-4039(00)73661-6

2-Deoxy taxol 2 was prepared in nine steps from baccatin III; the key step of the synthesis is a Barton-type deoxygenation at C-2. The compound was found to possess much reduced antitumor activity with respect to taxol.

Full text of DOI:10.1016/S0040-4039(00)73661-6

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