Bioorganic and Medicinal Chemistry Letters p. 6160 - 6163 (2007)
Update date:2022-08-04
Topics:
Jetter, Michele C.
Youngman, Mark A.
McNally, James J.
McDonnell, Mark E.
Zhang, Sui-Po
Dubin, Adrienne E.
Nasser, Nadia
Codd, Ellen E.
Flores, Christopher M.
Dax, Scott L.
We report on a series of α-substituted-β-tetralin-derived and related phenethyl-based isoquinolinyl and hydroxynaphthyl ureas as potent antagonists of the human TRPV1 receptor. The synthesis and Structure-activity relationships (SAR) of the series are described.
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