Absolute stereochemistry of alloxanic acid. A configurational relay for uricase reaction

Article abstract of DOI:10.1016/S0040-4039(00)60655-X

Alloxanic acid (3) was resolved by means of brucine and converted into its enantiomorphic esters 8 and amides 9; ethyl (-)-alloxanate whose absolute (S)-configuration was established by X-ray analysis served as configurational standard for the correlation of (+)-(R)-(3) and its precursor (-)-(S)-5-hydroxyisourate (2), the key uricolytic intermediate.