ASYMMETRIC SYNTHESIS XXI. ENANTIOSELECTIVE REDUCTION OF KETONES CATALYZED BY NEW (4S,5R)-4,5-DIPHENYL-1,3,2-OXAZABOROLIDINE

Article abstract of DOI:10.1016/0957-4166(94)80159-2

Oxazaborolidine prepared from (1R,2S)-1,2-diphenyl-2-aminoethanol with borane was used as catalyst in the enantioselective reduction of ketones.Excellent enantioselectivities with e.e. >99percent for acetophenone and e.e. >96percent for ω-bromo-acetophenone have been achieved.