Tetrahedron Letters p. 8633 - 8636 (1998)
Update date:2022-08-18
Topics:
Mulzer, Johann
Mantoulidis, Andreas
Oehler, Elisabeth
An easy access to four out of five naturally occurring epothilones (A- E, 1-5) is reported. Key steps are an enantioselective Mukaiyama type aldol reaction, (E)- and (Z)-selective olefinations, and a sulfone alkylation.
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