Chemical and Pharmaceutical Bulletin p. 776 - 779 (1983)
Update date:2022-08-17
Topics:
Kitamura
Narai
Hayashi
Tatsumi
The present paper is the first description of mammalian nitroreductases acting upon nitropolycyclic aromatic hydrocarbons. Rabbit liver microsomal and cytosolic fractions have ability to reduce 1-nitropyrene or 2-nitrofluorene to the corresponding amine under anaerobic conditions. The nitroreductase activity in the former fraction is mainly due to a cytochrome P-450 system and that in the latter fraction is due to aldehyde oxidase.
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