Bioorganic and Medicinal Chemistry Letters p. 897 - 902 (1997)
Update date:2022-08-11
Topics:
Baxter, Andrew D.
Bird, John
Bhogal, Ranjev
Massil, Tracy
Minton, Kevin J.
Montana, John
Owen, David A.
The preparation of a novel series of matrix metalloproteinase inhibitors is described, based on the use of a mercaptoacyl zinc binding moiety. The compounds have been tested in a model of rheumatoid arthritis and show good oral activity.
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