A practical synthesis of both enantiomers of 1-amino-2-propanol and propylene oxide

DOI: 10.1080/00397919308018583

Source and publish data:

Synthetic Communications p. 1071 - 1074 (1993)

Update date:2022-08-10

Topics:

Authors:

Rossen Rossen

Simpson Simpson

Wells Wells

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Article abstract of DOI:10.1080/00397919308018583

A practical large-scale synthesis of both enantiomers of 1-amino-2-propanol 1 from L- and D-threonine is described. Greater than 99% e.e. propylene oxide 2 is obtained from 1 through a diazotization under basic conditions.

Full text of DOI:10.1080/00397919308018583

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