
Synthetic Communications p. 1071 - 1074 (1993)
Update date:2022-08-10
Topics:
Rossen
Simpson
Wells
A practical large-scale synthesis of both enantiomers of 1-amino-2-propanol 1 from L- and D-threonine is described. Greater than 99% e.e. propylene oxide 2 is obtained from 1 through a diazotization under basic conditions.
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