Journal of Organic Chemistry p. 1719 - 1725 (1994)
Update date:2022-08-10
Topics:
Smith, Michael B.
Dembofsky, Bruce T.
Son, Young Chan
We have prepared a new chiral nonracemic reagent (5(R)-methyl-1-(chloromethyl)-2-pyrrolidinone) in enantiopure form that reacts with alcohols containing a stereogenic center to produce diastereomeric N-(alkoxymethyl)-2-pyrrolidinone derivatives.These derivatives exhibit large and easily observed diastereotopic signals in the proton NMR that allow direct determination of diastereomeric ratio (percent dr) for the product.
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