One-step synthesis of tertiary α-amino ketones and α-amino esters from amines and diazocarbonyl compounds

Article abstract of DOI:10.1055/s-1993-25984

Diazoketones and diazoesters react with tertiary amines in the presence of copper powder to form transient ammonium ylides. These ylides undergo facile [1,2]-shift from N to C (Stevens rearrangement) of the best migrating group. Overall, α-substituted α-a