Synthesis of some 5-perfluoroalkenyl derivatives of uracil

Article abstract of DOI:10.1016/0022-1139(94)03145-P

1,3-Dimethyl-5-iodouracil reacts smoothly with perfluorovinyl- (and E/Z-pentafluoropropenyl)-zinc iodides in the presence of Pd⁰ as a catalyst yielding the appropriate 5-perfluoroalkenyl derivatives of uracil at high and moderate yield.In an analogous reaction, 1,3-dimethyl-6-iodouracils did not yield the expected coupling products. - Keywords: Synthesis; Perfluoroalkenyl uracils; NMR spectroscopy; Coupling products; Palladium catalyst