Important Hydrogen Bond Networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Design Revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1

DOI: 10.1021/acs.jmedchem.5b01390

Source and publish data:

Journal of Medicinal Chemistry p. 282 - 293 (2016)

Update date:2022-08-17

Topics:

Authors:

Peng, Yi-Hui

Ueng, Shau-Hua

Tseng, Chen-Tso

Hung, Ming-Shiu

Song, Jen-Shin

Wu, Jian-Sung

Liao, Fang-Yu

Fan, Yu-Shiou

Wu, Mine-Hsine

Hsiao, Wen-Chi

Hsueh, Ching-Cheng

Lin, Shu-Yu

Cheng, Chia-Yi

Tu, Chih-Hsiang

Lee, Lung-Chun

Cheng, Ming-Fu

Shia, Kak-Shan

Shih, Chuan

Wu, Su-Ying

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Article abstract of DOI:10.1021/acs.jmedchem.5b01390

Indoleamine 2,3-dioxygenase 1 (IDO1), promoting immune escape of tumors, is a therapeutic target for the cancer immunotherapy. A number of IDO1 inhibitors have been identified, but only limited structural biology studies of IDO1 inhibitors are available t

Full text of DOI:10.1021/acs.jmedchem.5b01390

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