An improved procedure for the cyanation of aryl triflates: A convenient synthesis of 6-cyano-1,2,3,4-tetrahydroisoquinoline

Article abstract of DOI:10.1080/00397919508015477

A short synthesis of 6-cyano-1,2,3,4-tetrahydroisoquinoline is presented. The key step is an improved method of aryl triflate cyanation employing zinc(II)cyanide as the cyanide source.

Full text of DOI:10.1080/00397919508015477

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Synthetic Communications: An
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An Improved Procedure
for the Cyanation of Aryl
Triflates: A Convenient
Synthesis of 6-Cyano-1,2,3,4-
Tetrahydroisoquinoline
H. G. Selnick a , G. R. Smith a & A. J. Tebben a
a Department of Medicinal Chemistry, Merck
Research Laboratories, West Point, PA, 19486
Published online: 23 Sep 2006.
To cite this article: H. G. Selnick , G. R. Smith & A. J. Tebben (1995) An Improved
Procedure for the Cyanation of Aryl Triflates: A Convenient Synthesis of 6-
Cyano-1,2,3,4-Tetrahydroisoquinoline, Synthetic Communications: An International
Journal for Rapid Communication of Synthetic Organic Chemistry, 25:20, 3255-3261,
DOI: 10.1080/00397919508015477
To link to this article: http://dx.doi.org/10.1080/00397919508015477
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